Chromatography is an analytical method used for the identification, separation, and purification of the components and degrading products within Active Pharmaceutical Ingredients (APIs) to meet specific guidelines for drug efficacy implemented by regulatory bodies such as the FDA. Recently, pharmaceutical industries have witnessed a rapid increase in the demand for chromatography instruments such as gas chromatography, supercritical fluid chromatography, liquid chromatography, and gel permeation chromatography for quantitative and qualitative analysis of samples during drug development, particularly vaccine development and precision medicine.
The continuous adaptation of chromatographic techniques as a standard analytical tool across the pharmaceutical industry allows it to remain prevalent in meeting qualitative analysis across drug development. Driven by this factor, industrial leaders are emphasizing finding advanced chromatography solutions that offer efficacy sustainability, meet regulatory compliance, and ensure higher throughput. With ongoing research and advancements, it is expected that the global Chromatography Consumables and Chromatography Instrumentation Market will grow at a CAGR (Compound Annual Growth Rate) of 5.5%.
Chromatography Market Key Drivers
The existing chromatography methods provide low throughput, and scrapping of the thin-layer chromatography plates can adversely affect human health. It may lead to gene mutation if exposed to an open environment. Furthermore, the bulky designs and cost associated with the installation of chromatography for wide-scale use have restrained the chromatography market growth. To overcome the challenges, several large-scale and small-scale companies are shifting to follow major trends for gas chromatography and liquid chromatography that include smart technology, digitization, and automated technologies.
The majority of technical advancements in liquid chromatography are accelerating the demand for various chromatography consumables to perform analytical tests effortlessly. For instance, liquid chromatography with ultraviolet detection, liquid chromatography with high-resolution mass spectroscopy, and liquid chromatography with mass spectroscopy have been used in the food industry to address the issues regarding the quality of food and authenticity. Therefore, the adoption of various liquid chromatography consumables is expected to grow the market.
Major Trends to Follow in the Chromatography Market
Majority of the areas, particularly drug development and research in the pharmaceutical industry, require chromatography to access quality control and analysis of chemical purities for the product that is being developed. Some of the top trends in gas chromatography and liquid chromatography include:
Trends in the Gas Chromatography System
Some of the major trends companies are followed in gas chromatography systems are as follows:
▪ Miniature Techniques Rule The Platform
There is a high demand for portable gas chromatography systems as they offer significant advantages such as faster analysis times, reduced sample size, and increased mobility. Chromatography systems such as nano-scale and microscale chromatography systems help to reduce solvent consumption. Research and development processes that require on-site chemical analysis and environmental monitoring have benefitted from the compact systems.
▪ Integration of Automation
Integration of automation in gas chromatography systems with data processing tools and analytical techniques helps to streamline workflows and enhance overall efficiency. With automation tools in gas chromatography, researchers can perform rapid analysis screening with a higher accuracy rate within no time. Hence, they can invest time in designing new drugs and other therapeutic processes.
▪ Improvement in Column Technology
Column technology serves as the epicenter of innovation in gas chromatography. Innovative solutions, such as fused silica columns, capillary columns, and stationary phase, improve the sensitivity, resolution, and efficiency of the separation. Additionally, the innovation in novel stationary phases also helps to expand the applications of gas chromatography.
Trends in Liquid Chromatography Systems
Technology-driven liquid chromatography has increased the demand for chromatography consumables. Some instances of trends to be followed in liquid chromatography systems include:
▪ Ultra High Liquid Chromatography Systems (UHLCS)
The ultra-high-performance liquid chromatography is characterized by faster analysis and higher pressure. The trend has been driven by improved sensitivity, resolution, and higher throughput in numerous applications, including metabolomics, research, and proteomics. The UHLCS allows companies to meet the increasing demand for higher throughput analysis techniques than conventional chromatography.
▪ Green Chromatography Trend is Increasing
Pharmaceutical companies are looking for sustainable options with environment-friendly approaches in liquid chromatography. To meet sustainability, companies are adopting concepts of green chromatography that help to reduce energy consumption, optimize analytical processes, and minimize the waste of liquid columns.
In addition to this, the development of novel stationary phases like superficially porous particles has improved the separation efficiency of the particles, allowing the analysis of more complex particles to be effortless.
Recent Developments in the Chromatography Market
Several developments and collaborations have taken place in the field of chromatography to deliver optimal solutions for the development of drugs with utmost efficacy.
▪ In June 2023, Waters announced the establishment of a strategic partnership with Sartorius to provide optimized chromatography consumables and integrated process analytics systems such as Resolute® BioSMB™ multi-column chromatography system PATROL™, UltraPerformance Liquid Chromatography.
▪ In July 2023, Valmet announced the acquisition of the Process Gas Chromatography business of Siemens to strengthen its automation segment.
Top Chromatography Market Leaders
The leading chromatography market players shift to smart-connected technology that enables advanced diagnostics and provides flexibility in efficient operations. Examples of the top chromatography market players who are actively adapting innovative solutions include:
▪ Agilent Technologies
▪ Bio-Rad Laboratories
▪ Cytiva
▪ PerkinElmer
▪ Pall Corporation
▪ Sartorius
▪ Shimadzu
▪ Shodex
▪ ThermoFisher Scientific
▪ Waters Corporation
Concluding Remarks
Gas chromatography and liquid chromatography will continue to evolve and adapt technological advancements to meet the diverse requirements of pharmaceutical industries. The direction towards sustainability, miniaturization, improved column technologies, and automation helps to reshape the future of chromatography and allow companies to analyze data associated with drug development more precisely and efficiently. With continuous advancement, it is expected that the chromatography market will grow in the future.
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